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Large breweries usually apply more cost-effective processes to produce beer, such as the use of cheaper raw materials including supplementary grains. Craft breweries, on the other hand, use only barley malt as a raw material in beer production, the use of which may be related to the existence of different or richer phenolic compounds in craft beers (Cheiran, Manfroi, Kahmann, & Frazzon, 2019). During storage, phenolic compounds in beer cause turbidity by reacting with proteins. Large breweries usually utilize clarification process by removing these phenolic compounds. After the clarification, the beer has to be stabilized by exogenous antioxidants to enhance the flavor. While craft beer is not filtered and do not use additives, hence has higher contents of phenolic compounds than that in final commercial beer (Marques, Quelhas, Visentainer, & Monteiro, 2017).<ref name=yangao/>
Large breweries usually apply more cost-effective processes to produce beer, such as the use of cheaper raw materials including supplementary grains. Craft breweries, on the other hand, use only barley malt as a raw material in beer production, the use of which may be related to the existence of different or richer phenolic compounds in craft beers (Cheiran, Manfroi, Kahmann, & Frazzon, 2019). During storage, phenolic compounds in beer cause turbidity by reacting with proteins. Large breweries usually utilize clarification process by removing these phenolic compounds. After the clarification, the beer has to be stabilized by exogenous antioxidants to enhance the flavor. While craft beer is not filtered and do not use additives, hence has higher contents of phenolic compounds than that in final commercial beer (Marques, Quelhas, Visentainer, & Monteiro, 2017).<ref name=yangao/>
There is growing evidence that melanoidins have beneficial health properties, such as chemical prophylaxis, AOX, anti­ bacterial activity, and the ability to chelate different minerals (Adebayo et al., 2018; Delgado-Andrade & Morales, 2005; Morales et al., 2005). Barley malt melanoidins have been found to increase the activity of preventive enzymes in kidney and liver and reduce the level of oxidative stress in rodent plasma.<ref name=yangao/>